1-Boc-piperazine, also known as tert-butoxycarbonyl piperazine, is an organic compound widely used in organic synthesis, particularly as a protected form of piperazine. The term "Boc" stands for tert-butoxycarbonyl, a protecting group used to shield the nitrogen atom of piperazine during chemical reactions, making 1-Boc-piperazine a crucial intermediate in pharmaceuticals, fine chemicals, and peptide synthesis.
Chemical Structure and PropertiesChemical Name: 1-Boc-piperazine
Molecular Formula: C₉H₁₈N₂O₂
Molecular Weight: 186.25 g/mol
CAS Number: 57260-71-6
Physical Properties:
PropertyDescriptionAppearanceWhite crystalline powder or solidMelting Point40-42°CBoiling Point260°C (decomposes)SolubilitySoluble in organic solvents like ethanol, dichloromethane, and acetoneStabilityStable under normal conditions; reacts with acids or bases to remove Boc groupThe structure of 1-Boc-piperazine features a piperazine ring in which one nitrogen is protected by a tert-butoxycarbonyl group (-Boc), making it unreactive during certain reactions where the piperazine core is being modified.
