Where can I obtain information about the mechanism of action of Silagra 100 Mg ? | Forum

The mechanism of action of Silagra 100 mg is primarily attributed to its active ingredient, sildenafil citrate. Silagra is a medication used to treat erectile dysfunction (ED) in men. Sildenafil citrate belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Here's how it works: Inhibition of PDE5: Sildenafil citrate works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). PDE5 is responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis. By inhibiting PDE5, sildenafil increases the levels of cGMP, leading to smooth muscle relaxation and vasodilation in the penile blood vessels. Enhanced Blood Flow: As a result of smooth muscle relaxation and vasodilation, there is an increased blood flow to the penis. Silagra 100 mg increased blood flow helps men achieve and maintain an erection during sexual stimulation. Role of Nitric Oxide: The release of nitric oxide (NO) is stimulated by sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase, leading to the synthesis of cGMP from guanosine triphosphate (GTP). The accumulation of cGMP in the smooth muscle cells of the penile arteries causes relaxation and dilation of the blood vessels, allowing blood to flow into the penile tissues, resulting in an erection. Erection Maintenance: Silagra helps in maintaining the erection by preventing the degradation of cGMP by PDE5. This prolongs the action of cGMP, sustaining the relaxation of smooth muscle cells and the dilation of penile blood vessels during sexual activity. It's important to note that sexual stimulation is still required for Silagra to be effective. Without sexual arousal, the medication alone will not cause an erection. For more detailed information, you can consult medical literature, pharmacology textbooks, or reliable online sources such as medical websites or drug databases. Always ensure that the information you access is from reputable sources.