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Norco is a medication that is commonly prescribed to relieve moderate to severe pain. It belongs to a class of drugs called opioid analgesics, which work by binding to certain receptors in the brain and spinal cord to reduce the sensation of pain. Norco contains two main active ingredients: hydrocodone and acetaminophen. Hydrocodone is a powerful pain reliever, while acetaminophen helps to enhance the effects of hydrocodone.