Exosome in AD: Exosomes have been reported to serve as a role in the treatment of many diseases including central nervous system (CNS) disorders. Due to their small size, exosomes are used as effective carriers that deliver therapeutic drugs to target cells or tissues. Besides, mesenchymal stem cells (MSCs)-derived exosomes also play an essential role in CNS diseases therapies.
exosome lyophilization: Lyophilization is a useful technique that can be used for long-term stable preservation of exosomes. Lyophilized exosome standard is easy to transport and storage, and is stable for over 36 months at 4°C. Besides, lyophilized exosome can be used as control standards for FACS, WB, ELISA and other applications, as well as quantitative calibration standards for foreign and domestic exosomes in biological samples.
exosomal rna isolation kits: Exosomes play a critical role in cell-cell communication by shuttling functional protein or nucleic acid molecules in the target cell. They are involved in a variety of pathological processes such as cancer, infectious and neurodegenerative diseases. Increasing evidences have been suggested that exosomal RNA may be involved in the development or progression of specific human diseases. Some pathogenic miRNAs have been investigated as novel therapeutic targets or disease biomarkers in diverse diseases including cancer.
total exosome isolation reagent:
Creative Biolabs is very proud of providing the best purification reagents for exosome isolation from urine, biological fluids (i.e., plasma and serum), and cell culture supernatants. The reagents utilize chemical precipitation method to isolate exosomes and the method is simple and timesaving (about 1 hour), does not require special expensive experimental instruments, and only requires centrifuges.
genetically modified T cell: The concept of transferring T cells to patients (adoptive T cell transfers) to treat diseases has been established over the years through ex vivo manipulation, expansion, and reinfusion of T cells targeting specific viruses, for example for the treatment of viral infections, such as cytomegalovirus or Epstein Barr virus infection after hematopoietic stem cell transplantation.
Adnectin-based CAR-T cell:
Adnectin can be used as the antigen recognition domain in CAR constructs instead of scFv. We have designed multiple antigen-specific adnectin-CARs. Firstly, mRNA display is used to generate different adnectin clones, which target the target extracellular domain with different affinities. Then, different clones of target-specific adnectins were cloned upstream of the hinge domain to replace the scFv sequence. The adnectin-based extracellular domain is connected by the CD8α hinge and transmembrane domain, CD28 and 4-1BB costimulatory domains, and CD3ζ T cell receptor signaling domain. It is worth noting that we also provide adnectin-based first-generation and second-generation CARs.
Adjuvant Candidate Discovery for Cancer Vaccine:
Adjuvants can be added to the vaccines as immune agents to enhance the immune response. The mechanism of adjuvant relies on higher antibody production and longer protection. Here are different ways regarding the mechanisms.
By extending the presence of antigen in the blood to expand vaccine protection;By helping bind the antigens of antigen presenting cells to improve the immune response;By supporting the production of cytokines;By activating lymphocytes and macrophages.
oxalobacter formigenes probiotic: One of the most efficient oxalate-degrading organisms is O. formigenes, a Gram-negative, non-pathogenic, anaerobic commensal bacterium, naturally occurring in the colon of humans and other vertebrates and exclusively relying on oxalate to formate conversion as its energy source.
