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Adderall has been used as an off-label treatment for depression in patients who experience depression in combination with ADHD. Because stimulants can increase alertness, attention, and energy, they can feel like mood boosters for those experiencing depression.

Stimulants prescribed for ADHD include amphetamine (Adderall and Vyvanse) and methylphenidate (Concerta and Ritalin). Taking these medications is also shown to reduce the risk of developing depression in the future. The only non-stimulant medication that is FDA-approved for ADHD is atomoxetine (Strattera).

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