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Lortabis a prescription medication that contains a combination of hydrocodoneand acetaminophen. It is used to relieve moderate to severe pain, and works by blocking pain signals in the brain. Lortab is a controlled substance and can be habit-forming, so it should only be taken as directed by a healthcare professional.Lortab contains two active ingredients: hydrocodone and acetaminophen. Hydrocodone is an opioid pain reliever that works by binding to receptors in the brain and spinal cord, reducing the perception of pain. Acetaminop... more