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Norco contains acetaminophen, and taking excessive amounts can cause liver damage. It is important to avoid taking other medications that contain acetaminophen while using Norco. Cognitive impairment: Norco can cause drowsiness and impair cognitive functions, leading to reduced alertness and the ability to perform tasks that require focus and attention. Tolerance: With prolonged use, some individuals may develop tolerance to Norco, requiring higher doses to achieve the same level of pain relief. This can increase the risk of addict... more