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Sildenafil is a reversible selective inhibitor of specific FDE-5 cGMP. When sexual arousal causes local release of nitric oxide, inhibition of FDE-5 by sildenafil leads to increased concentration of cGMP in the cavernous body of the penis. The consequence of this is relaxation of arterial smooth muscles and blood flow to the tissues of the penis, which causes an erection. Aurogra 100 has no effect in the absence of sexual arousal.